Resveratrol, a polyphenolic activator of SIRT1, has been shown to increase the expression of eNOS [42] and the combination of resveratrol with the HMG-CoA reductase inhibitors (statins) increased the activation of eNOS resulting in increased functional recovery in a model of acute myocardial infarction [43]. The gene discussed is HMGCR; the disease is acute myocardial infarction.