Tumor necrosis factor (TNF)-α, nitric oxide (NO), and monocyte chemoattractant protein (MCP)-1 released from TAM are major intermediate molecules for tumor cell killing [67]–[69], and TAM associated vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) are independent predictor of poor prognostic factor in cancer patients [34]. This evidence concerns the gene CCL2 and neoplasm.