IL10 and lung carcinoma: As M2 type TAM express high level of interleukin-10 (IL-10) which can be used to discriminate between M1 and M2 macrophages [81], [82], a study assessed IL-10 expression in TAM, and found the high level of IL-10 in TAM significantly correlated with clinical staging and histologic poor differentiation in patients with lung cancer [83].