Lung metastatic tumor lesions were also significantly reduced in mice bearing 4T1-Esrp1-V1 tumors (11 lung metastatic tumor lesions in 4T1-control versus 1 lung metastatic tumor lesion in 4T1-Esrp1-V1) (Figure 5H). This evidence concerns the gene ESRP1 and metastatic neoplasm.