The more common toxicities (experienced by ≥20% of patients, all grades) included nausea and/or vomiting (54%), fatigue (53%), any hemorrhage (46%), diarrhea (44%), increased aspartate transaminase/alanine transaminase (38%), anorexia (37%), dry skin (30%), epistaxis (29%), acne (27%), mucositis (21%), and hypertension (20%). The gene discussed is GPT; the disease is hypertensive disorder.