CP and neoplasm: Histopathological examination confirmed that the normal control rats displayed normal neoplasm, the CYC treated group showed low grade differentiation demonstrated by giant multinucleated cells, infiltration of tissues and necrotic effects due to CYC on rats as well as decreased cell density, infiltration, higher level of fibrosis, reduction of inflammation, faster neovascularization, non-invasiveness of tissue architecture observed in CP-P treated rats.