Functionally, FKBP6 encodes a member of FK506 binding protein family and has been associated with male infertility in humans [32], [33], [34] and mice [33], while TRIM56 belongs to tripartite motif-containing gene family, members of which, like TRIM36 (alias HAPRIN), are involved in acrosome reaction of mammalian sperm [9], [17]. This evidence concerns the gene TRIM56 and male infertility.