IGHE and allergic disease: Subsequently, the function of IgE in antigen presentation was shown by Maurer et al.[30] However, the question whether allergy plays a role in practice still remained: measurement of specific serum IgE and skin prick tests or intracutaneous injections of allergen solutions are clinical routine to diagnose IgE-mediated sensitizations,[6,31] but in AE, they reveal often multiple sensitizations without clinical relevance.