The scientific in vitro laboratory diagnostic tests for allergy andtheir selection and interpretation, including radio-allergosorbent tests (CAP-RAST®); enzyme_linked immunosorbent assays (ELISAs); Western blotting; tests for inflammatory markers (eosinophil cationic protein [ECP] and tryptase); cellular antigen stimulation tests (CAST®), and histamine release assays. This evidence concerns the gene RNASE3 and allergic disease.