TACR2 and asthma: Bernstein et al [15] suggested a gene-to-environment interaction with IL4RA, CD14, and IL13. Based on studies showing the involvement of neurogenic inflammation in TDI-induced asthma, we used a single base extension to screen for 2 single-nucleotide polymorphism of neurokinin 2 receptor (NK2R) gene, 7853C > T and 11424G > A, in 70 patients with TDI-induced occupational asthma, 59 asymptomatic exposed controls, and 93 unexposed healthy controls [16].