We have reported that active atopic patients had a lower Foxp3+CD4+ ratio than asymptomatic controls having similar levels of serum IFN-γ, total IgE, and eosinophils, [25] suggesting that the development of clinical manifestations of allergic diseases may be determined by the ratio of proinflammatory T-cell subsets (Th17 and iTh2) versus Treg subsets. The gene discussed is IGHE; the disease is allergic disease.