The patient with more severe infections was of Turkish descent, had an early termination codon in TYK2 at amino acid position 767 caused by a 9-base pair DNA deletion in exon 16, had mildly elevated IgE (to a maximum of 218 IU/mL), no atopy, asthma, skin candidiasis, boils, folliculitis, or cold abscesses. This evidence concerns the gene IGHE and infection.