Revised clinical guidelines for the diagnosis of STAT3 mutant HIES have been proposed by Woellner et al.[7] A possible diagnosis can be made with IgE levels ≥1000 IU/mL plus a weighted score more than 30 based on 5 clinical findings: recurrent pneumonias, newborn rash, pathologic bone fractures, facial appearance, and high palate. This evidence concerns the gene IGHE and susceptibility to pneumonia measurement.