The key points of the Scandinavian PHO experiences are therefore as follows: First, and with caution because of the small number of individuals studied, Norwegian estimates indicate that if an individual, unknowingly IgE sensitized to the QAI-epitope (e.g. SUX) through PHO exposure, is subjected to the induction of general anesthesia with SUX intravenously, the risk of an IgE-mediated anaphylactic reaction is increased between 200 and 300 times (ie, from 1/5200 as estimated for the general population to 1/20) [16]. The gene discussed is IGHE; the disease is primary hypertrophic osteoarthropathy.