An international multicenter study comparing consuming and nonconsuming countries, found a significant association (P < 0.03) between the national consumptions of PHO, according to the INCB, and the percentages of sera with IgE antibodies to PHO using Phadiatop (IDD; Thermo Fisher Scientific) positive allergics as screening populations [8]. This evidence concerns the gene IGHE and primary hypertrophic osteoarthropathy.