Knowledge of evidence based therapeutic strategies (indications, mechanism ofaction, efficacy, benefits, side effects, and contraindications) for treatingallergic diseases, such as antihistamines, oral steroids, inhaled and intranasalsteroids, and anti-IgE [Ib]; limitations of injected steroids; leukotrieneand anti-IgE modifiers; theophylline; anticholinergics; bronchodilators; cromones;adrenaline/epinephrine [Ia]; allergen specific immunotherapy (sublingualand/or subcutaneous specific allergen immunotherapy) [Ib], and anti-IgEtherapy. The gene discussed is IGHE; the disease is glycogen storage disease VI.