RNASE3 and asthma: Sputum neutrophils were associated with increased cell lyses measured by sputum LDH and increased sputum LDH and ECP were associated with a longer hospital stay [9] The majority of asthma exacerbation is to be associated with viral respiratory tract infection [13] Respiratory viruses infect bronchial epithelial cells, resulting in epithelial activation and increased Neutrophil recruitment and activation [14].