IGHE and allergic disease: A topic dermatitis (AD) is a chronic and relapsing inflammatory cutaneous disease usually beginning at infancy, which is frequently associated with a family history of allergic diseases and often occurs in children with a personal history of other atopic disorders.[1-4] It is said to be the most common inflammatory skin disease in childhood;[5] it develops on dry skin with a hallmark of intense pruritus[2] and is associated with immunoglobulin E (IgE)-mediated sensitization in the majority of patients[2].