In a RCTwhere children with rhinosinusitis underwent a treatment with bacterial lysate(OM-85BV), a decrease in infectious episodes incidence and duration , their numberand the duration of concomitant treatments; furthermore, the clinical responseshowed a correlation with an increase in serum levels of IgA (active 6.53 ŷ0.96 vs placebo 6.81 ŷ 0.8).32 This evidence concerns the gene CD79A and ocular melanoma.