The World Allergy Organization, a worldwide federation ofnational and regional allergy and clinical immunology societies and organizationsdedicated to raising awareness and advancing excellence in clinical care, education,research, and training in allergy and clinical immunology, recommends that thisterminology be replaced with immunologic (IgE-mediated andnon-IgE-mediated [eg, IgG and immune complex complement-mediated]) andnonimmunologic anaphylaxis[26]. This evidence concerns the gene IGHE and allergic disease.