IGHE and asthma: It remains to be determined whether the increased useof antibiotics is involved in the stabilization or decrease observed, particularlyin the prevalence of non-immunoglobulin E (IgE)-mediated (sometimes termednonatopic) adult asthma, for which an infectious etiology has been proposed.6The results of long-term follow-up, derived from large multinational surveys,including the European Community Respiratory Health Survey and International Studyof Asthma and Allergies in Childhood (ISAAC), will be a good indicator of currentasthma trends on a global scale.