For example, immune deviation to a predominant TH1 response because of bacterial and viral infections was, at the beginning, the most obvious explanation; but there is also the suggestion that, instead of infections, there are other elements determining the evolution of the immune responses in children, and, in consequence, acting on the inception of IgE-mediated diseases, among them, the colonization of gut by commensal microbes[87-89] and inhaling cell wall products during infancy [88,90]. Here, IGHE is linked to infection.