There are a variety of acquired types of angioedema not due to C1-INH deficiency, and these may be bradykinin mediated [eg, angiotensin-converting enzyme inhibitor (ACE-I)-induced angioedema] or mast cell mediator histamine mediated (eg, urticarial angioedema, anaphylactic angioedema). This evidence concerns the gene ACE and angioedema.