IGHE and allergic respiratory disease: Respiratory allergy was diagnosed in those patients with asthma and/or allergic rhinitis with serum total IgE levels greater than those expected for age, with serum specific IgE to aeroallergens >0.35 IU/dL and/or with skin tests showing immediate hypersensitivity to mites >3 mm (compared with the negative control) [7,8].