Similarly, food allergy should be divided into "IgE-mediated food allergy" and "non-IgE-mediated food allergy" (Figure 3), and eczema should be divided as in Figure 4 These diseases themselves should derive their definitions from international documents such as the Global Initiative for Asthma [36] and Allergic Rhinitis and its Impact on Asthma guidelines [37]. This evidence concerns the gene IGHE and allergic rhinitis.