AFP and Cirrhosis: Regarding OS prediction, male gender (HR, 2.119; 95% CI, 1.040–4.320; P = 0.039), the presence of cirrhosis (HR, 2.319; 95% CI, 1.281–4.201; P = 0.005), baseline DCP level (HR, 1.000; 95% CI, 1.000–1.001; P = 0.028), number of tumors(HR, 1.443; 95% CI, 1.035-2.011; P = 0.030) and AFP response (HR, 0.276; 95% CI; 0.147–0.518; P < 0.001) were independent predictors of OS.