NR0B1 and Down syndrome: vHTS has been performed in many projects searching for therapeutics - for example, nuclear hormone receptor antagonists for cancer, diabetes and neurological diseases [39], CK2 inhibitors as antitumor agents [40], 17β-hydroxysteroid dehyrogenase type 1 inhibitors for breast cancer [41], and tyrosine phosphorylation regulated kinase 1A inhibitors for Down's syndrome [42].