ESR1 and neoplasm: These data indicate that tumors with histological grade (I, II and III), axillary lymph node status (positive, negative), tumor size (0–2, 2–5, and >5), ER/PR status (positive, negative) and HER2/neu status, exhibiting CCNB2 protein expression, have a more unfavorable prognosis, with an increased risk of overall shorter survival rates.