ERBB2 and neoplasm: Furthermore, several clinicopathological factors are also used to stratify patients into groups with different prognoses and to predict their response to adjuvant systemic therapies, including histological tumor grade, stage, size, age at diagnosis, axillary lymph node status, human epidermal growth factor receptor 2 (HER2/neu) status, steroid hormone receptor expression, and vascular invasion[4,5].