Multifactorial analysis revealed that DFS was significantly related to age (bad prognosis (b.p.)less than or equal to 37 years old), tumour size and histological grading (b.p. SBR = 3), and that OS was significantly related to tumour size and PR (b.p. PR less than or equal to 5 fmol mg-1 protein). The gene discussed is PGR; the disease is neoplasm.