In fact, the identified 12q24 linkage to multiple disorders including T2D [24], micro- and macrovascular disease [25-27], hypertension [2], body mass index and C-reactive protein [29], dyslipidemia [28], depression [32] and bipolar disorder [31] supports the idea that there could be a common underlying pathogenetic factor triggering the above-mentioned multiple disorders, such as an exaggerated inflammatory response or a deregulated autoimmune response leading to disease status. This evidence concerns the gene CRP and bipolar disorder.