IGHE and obesity due to melanocortin 4 receptor deficiency: Of note, the 12q24 locus is not only linked to T2D [24], macrovascular [25,26] and microvascular disease [27], but also to dyslipidemia [28], hypertension, obesity, [2], body mass index and C-reactive protein jointly [29], cat-specific IgE and total IgE in asthma [30], and most interestingly to bipolar disorder [31] and depression [32].