NM key modules(FOXO3_NM, TP53_NM) were enriched mostly in various cancer pathways and several cancer related processes such as cell cycle and apoptosis; M key modules (hsa_miR_16_M, has_let_7e_M, has_miR_30a_M, STAT1_M) were mostly enriched in signaling pathways related to tumor progression. This evidence concerns the gene FOXO3 and neoplasm.