In our study, mean MMP-2 and MMP-9 mRNA expression in the renal cell carcinomas was significantly higher than in the normal renal tissue (P <0.05), the levels of MMP-2 and MMP-9 mRNA expression were not correlated with tumor type or pathologic grade of renal cell carcinoma. The gene discussed is MMP2; the disease is hereditary clear cell renal cell carcinoma.