Similar results were obtained when the presence of specific IgE to common aeroallergens (asIgE) was used to define atopy (45.6% vs. 18.3% respectively) 14 Moreover, in the two Latin American study centres included in the ISAAC Phase II study (Pichincha Province, Ecuador and Uruguaiana, Brazil), only 11% of asthma was attributable to SPT 14, while a study of children of the same age living in rural Esmeraldas Province in Ecuador showed that only 2.4% of asthma was attributable to SPT 18. Here, IGHE is linked to asthma.