In recent years, there has been increasing interest in the role of various cytokines in the immunopathogenesis of lichen planus, which include interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), and transforming growth factor-β (TGF-β).3,4. This evidence concerns the gene TNF and lichen planus.