Fourth, and most importantly, identification of t(12;22)(q13;q12)(EWSR1-ATF1) or t(2;22)(q34;q12)(EWSR1/CREB1) fusion can be invaluable in distinguishing CCSST from PEComa [25]. This evidence concerns the gene CREB1 and neoplasm with perivascular epithelioid cell differentiation.