Since the description of the “Berlin patient”, who appears to have been functionally cured after two myeloablative peripheral blood stem cell transplants including one from a donor with a CCR5 deletion, and the recent description of two HIV-infected patients with undetectable HIV DNA after reduced intensity conditioning peripheral blood stem cell transplants, there has been a resurgence in the efforts to find a cure for chronic HIV infection [68, 69]. This evidence concerns the gene CCR5 and HIV infectious disease.