The SAE1 gene is involved in protein sumoylation process and is shown to interact with the ARX gene, which is involved in Autistic disorder (Sherr 2003; Rual et al. 2005; Ewing et al. 2007; Gareau and Lima 2010; Wilkinson et al. 2010; Szklarczyk et al. 2011). This evidence concerns the gene SAE1 and autism.