To determine whether previously mapped colon tumor susceptibility loci also contribute to differential susceptibility in the (ASF1)A N2 population, point-wise analysis was performed using the SNP marker nearest to previously identified Scc and Ccs loci (Table 1) (Angel et al. 2000; Jacoby et al. 1994; Moen et al. 1992, 1996; Ruivenkamp et al. 2003; van Wezel et al. 1996, 1999). Here, SERPINB3 is linked to colonic neoplasm.