Several MVI binding-partners have been identified so far in mammals: Disabled homolog 2 (Dab2), synapse-associated protein 97 (SAP97), GAIP-interacting protein COOH terminus (GIPC), lemur tyrosine kinase 2 (LMTK2), optineurin, phospholipase Cδ3, TRAF6-binding protein (T6BP), nuclear dot protein 52 (NDP52), translocated in liposarcoma (TLS) and dedicator of cytokinesis 7 (DOCK7) (Aschenbrenner et al. 2003; Chibalina et al. 2007; Majewski et al. 2012; Morris et al. 2002; Morriswood et al. 2007; Sakurai et al. 2011; Tamaki et al. 2009; Wu et al. 2002). The gene discussed is LMTK2; the disease is Tumor Lysis Syndrome.