SERPINE1 and coronary stenosis: Other univariate analyses show that significant coronary stenosis (above 75%) was related to seven polymorphisms: C667T MTHFR, K469E ICAM1, –1607 1G/2G MMP1, –1612 5A/6A MMP3, K167N LOX-1, –675 4G/5G PAI, and IVS7 FVII (Table 5).