APOE and Alzheimer disease: Clinical papers have included assessments of hippocampal asymmetry in AD (Barnes et al., 2005); the effect of APOE status on cortical thickness (Gutiérrez-Galve et al., 2009); the correlation between rate of atrophy and change in certain neuropsychological test scores (Schott et al., 2008); and the demonstration that the use of affine image registration (nine degrees of freedom) can correct for longitudinal changes in voxel size (Whitwell et al., 2004).