In this pathway, a critical enzyme required for the generation of 7α,25-diHC is CH25H, however, in our mouse experiments Ebi2 gene expression is downregulated in Mφ upon productive and nonproductive infection as well as polyI:C treatment, in an IFN-dependent manner (Figure 4C), suggesting that it is unlikely to be involved in the antiviral response. The gene discussed is GPR183; the disease is infection.