Simpler panels with ≤3components (for example PGA- Prothrombin Index, GGT and Apolipoprotein A1) performed as well as more complex panels –in a direct comparison AUROCs for cirrhosis PGA 0.89 Vs Fibrotest 0.84 Vs Hepascore 0.76, and for severe fibrosis/cirrhosis AUROCs PGA 0.84 Vs Fibrotest 0.80 Vs Hepascore 0.83 although this was only in one small study [25]. This evidence concerns the gene APOA1 and Cirrhosis.