The fusion transcript characteristic in the vast majority of myxoid liposarcomas is composed of FUS, which encodes for a RNA/DNA binding domain, and CHOP/DDIT3, which encodes for a transcription factor which dimerizes with CAAT/enhancer binding proteins (C/EBP) and negatively regulates genes involved in adipocytic differentiation including PPARγ. This evidence concerns the gene FUS and liposarcoma.