The vast majority of myxoid liposarcomas are characterized by a recurrent translocation involving t(12;16) (q13;p11) fusing the 3′-end promoter region of FUS/TLS (16p11) with the 5′-end of the CHOP/DDIT3 locus (12q13)[8-14]. The gene discussed is DDIT3; the disease is myxoid liposarcoma.