Oltipraz (4-methyl-5-[2-pyrazinyl]-1,2-dithiole-3-thione) is an Nrf2 inducer that suppresses the benzo[a]pyrene-induced gastric cancer formation, which is not observed in Nrf2-null mice (Ramos-Gomez et al., 2001). The gene discussed is NFE2L2; the disease is gastric cancer.