Recent studies revealed that Wilms tumor gene on the X chromosome (WTX) and PALB2, a major BRCA2 binding partner known as FANCN, have been shown to interact with the DC domain of KEAP1, inhibit the ubiquitination of Nrf2 and promote NRF2-dependent transcription (Camp et al., 2012; Ma et al., 2012). Here, PALB2 is linked to Nephroblastoma.