KEAP1 and cancer: The hypermethylation of the promoter region of KEAP1 gene has been identified in cancer cells generated in lung (Wang et al., 2008a; Muscarella et al., 2011b), prostate (Zhang et al., 2010), malignant glioma (Muscarella et al., 2011a), and colorectal cancers (Hanada et al., 2012).