We identified 18 secreted proteins in infected macrophages, including the protein orthologues heat shock protein 10, heat shock protein 70, DNA damage checkpoint protein (14-3-3 protein) and elongation factor 1 alpha (EF-1α), which have been previously described as exosomal proteins released into infected macrophages by Leishmania[63], [64], thereby suggesting that these proteins may be effectors present in the host cytosol after the infection by macrophages has been established. The gene discussed is EEF1A1; the disease is infection.