HCFC1 and Myocardial fibrosis: Other possible mechanisms that may also contribute to the prevention of UNX-induced myocardial fibrosis include inhibition of fibroblast proliferation which may be linked to CNP and GC-B activation, given the predominance of GC-B receptors on cardiac fibroblasts [32] and indeed our previous report demonstrated that CD-NP suppresses hCF proliferation in vitro[6].