In order to investigate if enhanced IL-10 signaling as a result of IL-10R2 induction by LGG would be protective against injury in the developing intestine, we used a previously characterized model of NEC-like inflammation in which gut mucosal injury is induced in 2 week-old mice by intraperitoneal administration of PAF and LPS [51], [52], [53]. The gene discussed is IL10; the disease is necrotizing enterocolitis.