The upregulation of non-muscle myosin in FSHD, together with the upregulation of thrombospondin, GPI anchor Thy-1 glycoprotein, filamin-A, vimentin and perlecan, suggests that cell adhesion is altered in FSHD myotubes. This evidence concerns the gene HSPG2 and facioscapulohumeral muscular dystrophy.