When fed OVA, unstimulated BMDC or BMDC treated with c.m. from unstressed tumor cells (Vehcm) efficiently induced OT-I CD8+ T cell activation and proliferation, as demonstrated by conversion to an activated CD69+/CD25+/CD62Llo/CD44+ phenotype (Fig. 4A) and by 5-(and-6)-carboxyfluorescein diacetate, succinimidyl ester (CFDA-SE) dilution (Fig. 4B), respectively. The gene discussed is CD44; the disease is neoplasm.