In this exploratory study, the effects of 89 SLC22A1 SNPs identified on whole gene sequencing, as well as 11 candidate SNPs from ABCB1, ABCG2, CYP3A5 and PXR genes on IM pharmacokinetics were examined in a cohort of healthy subjects belonging to Asian populations from Singapore, consisting of Chinese, Malay and Indian ethnic groups as well as patients with Ph+ chronic phase CML. This evidence concerns the gene ABCG2 and chronic myelogenous leukemia, BCR-ABL1 positive.