Activation of this receptor on the surface of 1-LN, and DU-145 human prostate cancer cells, and A375 melanoma cells by α2M* triggers pro-proliferation and pro-survival cellular responses [5]–[10]; therefore, it has been argued that upregulation of cell surface GRP78 is part of the aggressive phenotype in cancer. The gene discussed is A2M; the disease is prostate carcinoma.