The OR for poor functional outcome was greater in the highest tertile (5.73, P = 0.03) than in the lowest tertile of D2 YKL-40 in AIS patients after adjusting for age, sex, hypertension, diabetes mellitus, hypercholesterolemia, smoking, previous stroke and D2 CRP level. The gene discussed is CRP; the disease is familial hypercholesterolemia.