Serum YKL-40 levels of non-diabetic (D1 and D2>200 ng/mL, P<0.05) and diabetic (D1 and D2>200 ng/mL, P<0.05) AIS patients were significantly higher than those of non-diabetic (41 ng/mL) and diabetic (57 ng/mL) controls. Here, CHI3L1 is linked to androgen insensitivity syndrome.